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omid Jazayeri

omid Jazayeri

Academic rank: Assistant Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Science
Address:
Phone: 011-35302450

Research

Title
Investigation of the association between rs12129861 polymorphism in PDZK1 gene with the risk of preeclampsia
Type
Presentation
Keywords
preeclampsia,rs12129861,association
Year
2023
Researchers Maedeh Rahrovi ، omid Jazayeri ، Mohammad Karimian ، Ali Taravati

Abstract

Pre-eclampsia is a common inherited pregnancy complication with various genetic and environmental causes that is characterized by high blood pressure and proteinuria. Extensive research has focused on the role of genetic factors in the occurrence of this disease, many of which show that gene polymorphisms play role in the diagnosis of preeclampsia. The aim of this study is to investigate the relationship between the rs12129861 polymorphism and the risk of preeclampsia. In this case-control study, the genotypes of 121 pregnant women with preeclampsia and 74 healthy pregnant women were investigated for this polymorphism by PCR-RFLP method. According to the observed results, it can be said that the dominant inheritance pattern in rs12129861 polymorphism has a significant relationship with the disease and increases the risk of preeclampsia (OR: 2.29, p-value: 0.041)