مشخصات پژوهش

عنوان	Synthesis, characterization, and evaluation of antioxidant and antibacterial activities of novel indole-hydrazono thiazolidinones
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Three-component reactions  Dialkyl acetylenedicarboxylate  Maleimide  Indole-hydrazono thiazolidinones  Antioxidant activities  Antibacterial activities
چکیده	Three-component reactions of oxindole derivatives, thiosemicarbazide with dialkyl acetylenedicarboxylate (or maleimide) led to novel indole-hydrazono thiazolidinones in high-to-excellent yields. The antioxidant activities of the synthesized compounds were studied by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. Among the products, those with amide moiety exhibited better antioxidant activities than other ester derivatives of indole-hydrazono thiazolidinones. Minimum bactericidal concentration (MBC) was evaluated against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) at different concentrations. However, the MBC values for compounds with amide group in their skeleton exhibited higher antibacterial activity than compounds with ester group. Therefore, it is assumed that these compounds could be used as effective antioxidant and antibacterial agents.
پژوهشگران	مجتبی محسنی (نفر سوم)، مریم پورشب (نفر دوم)، سکینه اصغری قراخیلی (نفر اول)