مشخصات پژوهش

عنوان	Synthesis and evaluation of novel isatin and 5-isatinylidenerhodanine-based furan derivatives as antibacterial agents
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	5-Isatinylidenerhodanine, Isocyanide, Furan, Antibacterial activity
چکیده	A simple synthesis of novel 5-isatinylidenerhodanine-based furan derivatives via a multi-component reaction is described. The reactive 1:1 intermediate, produced by the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates, was trapped at reflux temperature by acidic derivatives of isatin and 5-isatinylidenerhodanine to yield isatin and 5-isatinylidenerhodanine-based poly functionalized furan rings in fairly good yields. The products were analyzed for antibacterial activity against Gram-positive and Gram-negative bacteria. The results indicate that the synthesized compounds are effective against bacterial growth retardation activity to some extent and their effectiveness is higher for Escherichia coli.
پژوهشگران	مجتبی محسنی (نفر چهارم)، سمیه راثی (نفر سوم)، سکینه اصغری قراخیلی (نفر دوم)، ربابه بهارفر (نفر اول)