مشخصات پژوهش

عنوان	Preparation of nanomagnetic alginate modified by histidine as an antibacterial agent and a reusable green catalyst for the three-component synthesis of 2-amino-4H-chromenes and tetrahydropyrimidines
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Histidine–alginate nanomagnetic catalyst, Green catalyst, 2-Amino-4H-chromenes, 1,2,3,6-Tetrahydro pyrimidines, Antibacterial agent
چکیده	A novel acid–base nanocatalyst (MNPs@Alg-Pr-His) was synthesized using available materials (nanomagnetic alginate core and histidine) via a facile strategy. After characterization, its efciency was investigated in the synthesis of 2-amino- 4H-chromene and 1,2,3,6-tetrahydropyrimidine derivatives. This nanobiocatalyst showed remarkable catalytic efciency in both reactions (the reaction yields for the frst reaction: 89–96% and for the second reaction: 68–85%). This catalyst was reusable and recyclable and still showed good activity after fve runs. The antibacterial efect of the histidine, alginate, and MNPs@Alg-Pr-His was evaluated against a Gram-positive bacterium (S.aureus) and a Gram-negative bacterium (E. coli) by the disk difusion method. It is noticeable that MNPs@Alg-Pr-His, unlike histidine and alginate, showed more antibacterial activity against Gram-negative bacterium (28.0 ±1.4) than Gram-positive bacterium (19.0±1.4).
پژوهشگران	مجتبی محسنی (نفر چهارم)، بهروز ملکی (نفر سوم)، سکینه اصغری قراخیلی (نفر دوم)، مقدسه کشوری کناری (نفر اول)