مشخصات پژوهش

صفحه نخست /Protective effect of Vitex ...
عنوان Protective effect of Vitex agnus-castus fruit on lipid peroxidation induced by repeated exposure to toluene in the hippocampal area of mice
نوع پژوهش مقاله ارائه شده
کلیدواژه‌ها Vitex-agnus castus, toluene, hippocampus, mice
چکیده Introduction: Toluene is an organic solvent widely used in many industrial processes and the central nervous system is a primary target in both acute and chronic exposure to toluene toxicity. Vitex agnus castus (VAC) fruit is a source of phytoestrogens, flavonoids, and apigenin, and has a great antioxidant ability. The purpose of this study was to evaluate the protective effect of VAC fruit on toluene-induced lipid peroxidation in mice brains. Method & Materials: In the experimental study, 50 male mice (25-35 g) were divided into five groups: control, vehicle, VAC fruit extract, toluene, and toluene plus VAC fruit extract (100 mg/kg). Toluene and the extract were injected intraperitoneally for 14 consecutive days. In the toluene plus VAC fruit extract group, first, toluene was injected and after 2 hours the extract was injected. After 14 days, the hippocampal area was extracted and lipid peroxidation was evaluated by measuring the MDA level. Results: Toluene caused a significant increase (P < 0.001) in MDA level compared to the control group. Whereas treatment with the VAC fruit extract caused a significant decrease (P < 0.001) MDA level compared to the toluene group. Discussion: Our result showed that VAC fruit treatment significantly increases toluene-induced lipid peroxidation may be via antioxidant activity. Therefore, the neuroprotective effects of VAC fruit can be useful in medicine.
پژوهشگران فرشته میر محمدرضایی (نفر سوم)، اکبر حاجی زاده مقدم (نفر دوم)، سروش فرهادی (نفر اول)