مشخصات پژوهش

عنوان	Renoprotective effect of Eryngium caucasicum in Gentamicin-induced nephrotoxic mice
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Eryngium caucasicum, renotoxicity, Gentamicin, creatinine, urea, BUN
چکیده	Recent studies show that hydrogen peroxide free radicals have an important role in the renal damage induced by Gentamicin. Previously we studied the hydrogen peroxide scavenging activity of Eryngium caucasicum. This work was conducted to evaluate the possible renoprotective effect of Eryngium caucasicum against Gentamicin-induced renotoxicity. Extracts at the doses 200 and 400 mg/kg/day for 10 consecutive days, by intraperitoneal route (i.p.) offered renoprotective action by change in the blood urea nitrogen (BUN), serum urea and creatinine. Results show that an extract at 400 mg/kg/day shows better activity than other tested samples. In conclusion, the extracts showed significant renoprotective activity compared with the control group.
پژوهشگران	سید محمد نبوی (نفر ششم به بعد)، ناصر جعفری (نفر پنجم)، سید فاضل نبوی (نفر چهارم)، اکبر حاجی زاده مقدم (نفر سوم)، محمدعلی ابراهیم زاده (نفر دوم)، شهرام اسلامی (نفر اول)