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Title
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Synthesis and characterization of sulfide, sulfoxide and sulfone derivatives of thiopyran: antimicrobial evaluation
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Type
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JournalPaper
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Keywords
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Antibacterial , Antifungal , Thiopyran S-oxides , Thiopyran S , S-dioxides , Thiopyrans
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Abstract
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A series of thiopyran derivatives and their oxidized analogous forms were synthesized and characterized by FT-IR, 1H, 13C, 31P NMR and mass spectroscopy techniques. The antibacterial and antifungal activities of these synthesized materials were evaluated against Staphylococcus aureus and Bacillus subtilis, as Gram-positive bacteria, and Escherichia coli and Pseudomonas aeruginosa, as Gram-negative bacteria, as well as the fungus Candida albicans. The results revealed that thiopyran S,S-dioxides are the most effective against all the bacteria studied in this work. Furthermore, thiopyran S-oxides showed excellent antifungal activity against Candida albicans.
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Researchers
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Sakineh Asghari (Second Researcher), Mojtaba Mohseni (Fourth Researcher), mahmood tajbakhsh (Third Researcher), Ghasem Firouzzade Pasha (First Researcher)
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