مشخصات پژوهش

عنوان	Diastereoselective synthesis of pyrrolo[1, 2-c]imidazoles using chiral thiohydantoins, malononitrile, and aldehydes and evaluation of their antioxidant and antibacterial activities
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Diastereo selective, chiral thiohydantoins,pyrrolo[1, 2-c]imidazoles,antioxidant
چکیده	Diastereoselective synthesis of pyrrolo[1,2-c]imidazoles is reported from threecomponent reaction of chiral thiohydantoins, aldehydes, and malononitrile in the presence of NEt3. The antioxidant properties of the obtained products were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among the products, compound 4l possessing NH2 and NH groups and bromine atom at 4-position of the aromatic ring displayed the highest antioxidant activity (90%). Also, their antibacterial activities were explored against grampositive and gram-negative bacteria using disc diffusion method. Among the synthesized compounds, 4a with chlorine atom at para position of the aromatic ring, and methyl group (the smallest alkyl group) at 7-position, displayed the best antibacterial activity against the tested gram-positive bacteria.
پژوهشگران	خسرو جدیدی (نفر سوم)، سکینه اصغری قراخیلی (نفر دوم)، خدیجه ملانژاد (نفر اول)