مشخصات پژوهش

عنوان	Regioselective synthesis and antibacterial activity of 3-(cyanoacetyl)indole-based kojic acid derivatives
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Three-component reaction, 3-(Cyanoacetyl)indole, Kojic acid, Ammonium acetate, Antibacterial activities
چکیده	A simple and facile protocol for the regioselective synthesis of diastereomeric 3-substituted indole derivatives is described by the three-component condensation of 3-(cyanoacetyl)indole, aldehydes, and kojic acid in the presence of ammonium acetate as catalyst. The synthesized compounds were tested for their antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. One compound showed good activity against B. subtilis compared with the standard drugs gentamicin and chloramphenicol.
پژوهشگران	مریم کیانی (نفر سوم)، سکینه اصغری قراخیلی (نفر دوم)، ربابه بهارفر (نفر اول)