مشخصات پژوهش

عنوان	Asymmetric synthesis of α-bromohydrins by carrot root as biocatalyst and conversion to enantiopure β-hydroxytriazoles and styrene oxides using click chemistry and SN2 ring-closure
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Bioreduction, Biocatalyst, Carrot root, Chiral α-halohydrins, Chiral β-hydroxytriazoles, Chiral styrene oxides
چکیده	In this study we have combined the bioreduction of α-bromoketones using carrot root as biocatalyst and click chemistry for the preparation of enantiopure β-hydroxytriazoles in excellent enantiomeric excesses and yields. Moreover, we have utilized chiral α-halohydrins for the synthesis of enantiopure styrene oxides in very good yields and enantiomeric excesses. Structural assignments of the products were based on their 1H and 13C NMR data and their optical rotations. The enantiomeric excess of the chiral products was obtained by HPLC analysis.
پژوهشگران	سکینه مسگر (نفر سوم)، مریم مهاجرانی (نفر دوم)، رحمان حسین زاده (نفر اول)