مشخصات پژوهش

عنوان	Cannabinoid System of the Lateral Septum in the Modulation of Anxiety-like Behaviors in Rats
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Anxiety, cannabinoid, lateral septum, plus-maze test, rat
چکیده	Backgrounds: A large body of evidence suggests that the cannabinoid CB receptor plays a key role in the regulation of emotional behaviors. The present study was designed to evaluate the effects of CB 1 1 agonist and antagonist on anxiety-like behaviors in the lateral septum (LS) region of the rat brain using elevated plus maze test. Method: Rats were anesthetized with ketamine and xylazine and special cannulas were inserted stereotaxically into the LS region. After 1 week of recovery, the effects of intra-LS administration of the CB 1 receptor antagonist, AM251, 1 Results: 55,212-2-induced anxiogenic-like effects. Conclusions: The results suggest that the cannabinoid system of the lateral septum modulates anxiety-like behavior through CB 1 receptor.
پژوهشگران	اکبر حاجی زاده مقدم (نفر اول)، علی روحبخش (نفر چهارم)، سید رضا فاطمی طباطبایی (نفر سوم)، راتا بیگدلو (نفر دوم)