مشخصات پژوهش

عنوان	Behavioral Effects of 2,3-Dihydro- and Oxoisoaporphine Derivatives in Post Stroke-Depressive Like Behavior in Male Balb/c Mice
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Oxoisoaporphine, antidepressant, depressive-like behavior, acute ischemic stroke.
چکیده	Abstract: In this study, antidepressant-like effects of intra-cerebroventricularly administration of oxoisoaporphine deriva- tives in post stroke-depressive like behavior were examined through despair swimming and tail suspension models. For this aim, acute ischemic stroke was induced by bilateral common carotid arteries occlusion which significantly changed the normal behaviors of male balb/c mice. We performed stroke-induced anhedonia test as a key result of post strokedepressive like behavior by determination of sucrose consumption. Results show that some 2,3-dihydro- and oxoisoaporphine derivatives modified the abnormality in the behaviors through decreasing in the immobility time in tail suspension and despair swimming models and increasing in the swimming and climbing times in despair swimming model. We concluded that these alkaloids showed antidepressant actions and therefore can be used for treatment of post strokedepressive like behavior in acute ischemic stroke patients.
پژوهشگران	اندری گارسیا سیلوا (نفر ششم به بعد)، اکبر حاجی زاده مقدم (نفر پنجم)، سید محمد نبوی (نفر سوم)، ماریا داگلیا (نفر چهارم)، ادوآرادو سوبارزو (نفر دوم)، سید فاضل نبوی (نفر اول)