مشخصات پژوهش

عنوان	Guanidine hydrochloride as an organocatalyst for N-Boc protection of amino groups
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Protection, Organocatalysis, (Boc)2O, Amines, Amino acids
چکیده	A simple and efficient method for the chemoselective N-Boc protection of the amine moiety in a variety of compounds is described using di-tert-butyl dicarbonate and guanidine hydrochloride as an organocatalyst in ethanol at 35–40 C. Selective mono-N-Boc protection of diamines and chemoselective protection of hydroxylamines without formation of any side products is achieved. Amino acids and peptides are N-Boc protected efficiently in excellent yields under convenient reaction conditions.
پژوهشگران	صمد خاکسار (نفر چهارم)، محمود تاجبخش (نفر دوم)، فاطمه جهانی بهنمیری (نفر اول)، حمید گلچوبیان (نفر سوم)