مشخصات پژوهش

عنوان	New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	sesterterpenoid, salvia mirzayanii, absolute configuration, cytotoxic activity, diterpenoid
چکیده	Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (1–6), and one new nor-diterpenoid (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS) and DP4+ NMR chemical shift probability calculation technique. Moreover, the absolute configuration of compounds was determined by using electronic circular dichroism spectroscopy. Evaluation of antiproliferative properties of compounds isolated against four human melanoma cancer cells displayed no cytotoxic activity at the concentration range used.
پژوهشگران	مصطفی علی لو (نفر ششم به بعد)، هرمن استوپنر (نفر ششم به بعد)، مارسل کویتکوفسکی (نفر ششم به بعد)، ژاکوب تراپمر (نفر پنجم)، صمد نجاد ابراهیمی (نفر چهارم)، یعقوب صرافی (نفر سوم)، مهدی مریدی فریمانی (نفر دوم)، فروغ میرزانیا (نفر اول)