مشخصات پژوهش

عنوان	Protective Effects of Curcumin and its Nano- Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	antioxidant activity, inflammation, mice model, nano-phytosome
چکیده	Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nanophytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model. Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated. Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P<0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P<0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P<0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P<0.05). Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.
پژوهشگران	نصراله مرادی کر (نفر چهارم)، صدیقه خانجانی (نفر سوم)، اکبر حاجی زاده مقدم (نفر دوم)، سعیده برادران (نفر اول)