1403/01/09
محمود تاجبخش

محمود تاجبخش

مرتبه علمی: استاد
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده شیمی
نشانی:
تلفن: 09111146981

مشخصات پژوهش

عنوان
Synthesis and antimicrobial evaluation of some new bicyclopyrazolone‐based thiopyran ring systems
نوع پژوهش
JournalPaper
کلیدواژه‌ها
antibacterial, antifungal, bicyclopyrazolones, hydrazine derivatives, methyl 4-oxotetrahydro-2H-thiopyran-3-carboxylate
سال
2019
مجله JOURNAL OF THE CHINESE CHEMICAL SOCIETY
شناسه DOI
پژوهشگران Ghasem Firouzzade Pasha ، Sakineh Asghari ، mahmood tajbakhsh ، Mojtaba Mohseni

چکیده

A series of bicyclopyrazolones were synthesized from the condensation reaction of methyl 4‐oxotetrahydro‐2H‐thiopyran‐3‐carboxylate with hydrazine derivatives in ethanol. All synthesized products were characterized by FT‐IR, 1H, and 13C NMR spectral data, elemental analyses, and mass spectrometry. The antibacterial and antifungal activities of these compounds were evaluated against Staphylococcus aureus and Bacillus subtilis as Gram‐positive bacteria, Escherichia coli and Pseudomonas aeruginosa as Gram‐negative bacteria, and the fungus Candida albicans. The results revealed that bicyclopyrazolones including an aryl or aryl sulfonyl group in the N‐2 position of the pyrazolone moiety are the most effective against all the microorganisms studied in this work.