2024 : 5 : 25
Shadmehr Mirdar Harijani

Shadmehr Mirdar Harijani

Academic rank: Professor
Education: PhD.
Faculty: Faculty of Physical Education and Sports Sciences
Address: Professor of Exercise Physiology, Dep. of Exercise physiology, Faculty of sports Sciences, University of Mazandaran P.O.Box 47415-388 Babolsar,Mazandaran Province, IRAN Tel: +98 +111+35302201 & 35302254 Fax: +98+ 111+35302201
Phone: 01135302254


The TNF-a, P53 protein response and lung respiratory changes related to exercise, chronic hypoxia and Adiantum capillus-veneris supplementation
apoptosis, lung, interval training, respiratory surface
Journal Advances in Respiratory Medicine
Researchers Mehdi Yadegari ، Simin Riahy ، Shadmehr Mirdar Harijani ، Gholamreza Hamidian ، Seyed Mohsen Afkhami ، ayoub saeidi ، fatma rhibi ، Abderraouf Ben Abderrahman ، Anthony C Hackney ، Hassane Zouhal


Introduction: Evidence suggests that hypoxia and high-intensity exercise training can increase apoptosis of lung cells and Adiantum capillus-veneris (Ac-v) extract can have anti-apoptotic effects. Thus, the aim of the present study was to investigate the effect of chronic hypoxia and the (Ac-v) extraction as a supplement on TNF-a and P53 protein expression as well as the respiratory surface. Material and methods: 24 healthy Wistar rats (age = 4 weeks, weight = 72 = 9 gr) were trained using interval training for 6 weeks followed by a 3-week stay in hypoxia conditions. Half of the hypoxia samples received 500 ml/gr/per body weight daily (Ac-v) within 3 weeks of hypoxia. At the end, the lung tissue was removed for histological and immunohistological analysis. Results: After 3 weeks of hypoxia exposure following 6 weeks of exercise, expression of P53 and TNF-a increased and the respiratory surface decreased (p ≤ 0.05). After 3 weeks of taking the Ac-v extract during hypoxia exposure, reduced P53 and TNF-a expression and the increased respiratory surface were observed (p ≤ 0.05). Conclusions: Chronic hypoxia may be considered as a strong stimulus leading to the expression of proteins involved in apoptosis and tissue disruption. However, our findings suggest that the antioxidative properties of Ac-v extract could decrease the destructive structural and molecular events that happen along with hypoxia exposure or intense exercise training.