Cancer stem cells ( constitute a small faction of cells within tumors, recognized for their pivotal role in initiating, growing, and relapsing cancer 1 CSCs possess distinctive traits, including self renewal capacity, multi directional differentiation, plasticity, tumorigenicity, treatment resistance, specific cell surface markers, and high metastatic potential 2 Recently, cold atmospheric plasma ( based therapies have emerged as one of the most promising therapeutic approaches for maximizing drug delivery and targeting CSCs 3 CAP, a gas mixture comprising photons, neutral and charged particles (electrons and ions), as well as free radicals, demonstrates notable potential in various biomedical realms by generating reactive oxygen and nitrogen species ( CAP has demonstrated noteworthy promise in the realm of cancer therapy by inducing oxidative stress through the formation of RONS
