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Title
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A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition
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Type
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JournalPaper
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Keywords
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1,2,3‐triazole, antidiabetic activity, molecular docking, Schiff base, α‐glucosidase
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Abstract
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A series of new Schiff bases bearing 1,2,3-triazole 12a‒o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase.
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Researchers
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mohammad mahdavi (Not In First Six Researchers), Mirhamed Hajimiri (Not In First Six Researchers), Bagher Larijani (Not In First Six Researchers), Haleh Hamedifar (Not In First Six Researchers), Fatemeh Bandarian (Not In First Six Researchers), Mohammad Ali Faramarzi (Not In First Six Researchers), Nasser Samadi (Not In First Six Researchers), Zeinab Sharafi (Fifth Researcher), Sepideh Rezaei (Third Researcher), Ensieh Nasli-Esfahani (First Researcher), Yaghoub Sarrafi (Fourth Researcher), Maryam Mohammadi-Khanaposhtani (Second Researcher)
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