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Title Four-Component Reaction between Ethyl Benzoylacetate, Hydroxylamine, Aldehydes and Malononitrile: Synthesis of Isoxazol-5(2H)-Ones
Type JournalPaper
Keywords Hydroxylamine; Aromatic aldehyde; Malononitrile; Isoxazol-5(2H)-ones; Multi-component reactions; Green chemistry.
Abstract We present herein a new and efficient four-component synthesis of isoxazol-5(2H)-ones involving ring closing/Knoevenagel condensation/Michael addition sequential reactions.
Researchers Mohammad Eghtedari (Second Researcher), Yaghoub Sarrafi (First Researcher)