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Title
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Efficient Synthesis of Rhodanine-Based Amides via Passerini Reaction using Tetramethylguanidine-Functionalized Silica Nanoparticles as Reusable Catalyst
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Type
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JournalPaper
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Keywords
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Passerini reaction, rhodanine-N-acetic acid, tetramethylguanidine, heterogeneous catalysis, antibacterial agents
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Abstract
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Novel rhodanine-based amide derivatives were prepared in good yields via Passerini reaction of rhodanine-N-acetic acid with aromatic aldehydes and tert-butyl isocyanide in the presence of tetramethylguanidine immobilized on silica nanoparticles (TMG-SiO2 NPs) as a heterogeneous base catalyst. The synthesized compounds were evaluated for their antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis.
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Researchers
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Mojtaba Mohseni (Fourth Researcher), Sheida Barzegar (Third Researcher), Razieh Azimi (Second Researcher), Robabeh Baharfar (First Researcher)
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