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Title
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MOF-derived Co2CuS4 nanoparticles with gold-decorated reduced graphene oxide for electrochemical determination of chloramphenicol in real samples
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Type
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JournalPaper
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Keywords
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Sensor, Antibiotic, Dual-core MOF, Transition bi-metallic sulfide, Milk, Honey
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Abstract
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Despite the beneficial effects of antibiotics such as chloramphenicol (CAP), they exert some destructive impacts on human health. We designed an electrochemical sensor based on reduced graphene oxide (rGO)/Au/Co2CuS4 nanohybrid for determination of CAP in food and biological samples. The Co2CuS4 was synthesized from binuclear metal-organic framework (CoCu-BDC) through a two-step process. Nanohybrid was characterized by X-ray photoelectron spectroscopy and transmission electron microscopy. The rGO/Au/Co2CuS4 provides more active sites and good electrical conductivity to reduce charge transfer resistance and improve the electrocatalytic activity for determination of CAP. The prepared sensor has a wide linear range from 7 to 141 nM with a limit of detection of 2.5 nM and a limit of quantification of 21.92 nM. It also provided high selectivity and repeatability with a relative standard deviation of 2.6%. Stability studies showed that the electrode has acceptable performance with efficiency of 95% after 33 days.
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Researchers
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Sayedeh Farimah Mousavi (Fourth Researcher), Sayed Reza Hosseini-zavvarmahalleh (Third Researcher), Shahram Ghasemi (Second Researcher), Seyed Mohammad Amin Daei Naseri (First Researcher)
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