Research Info

Title	Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors
Type	JournalPaper
Keywords	3-ArylcoumarinsDABCOsalicylaldehydesolvent-freesoybean 15-lipoxygenase
Abstract	A series of coumarin–resveratrol hybrids, 3-arylcoumarin derivatives 3a–u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities.
Researchers	Alireza Foroumadi (Not In First Six Researchers), Abbas Shafiee (Not In First Six Researchers), Mohammad Mahdavi (Not In First Six Researchers), Alireza Moradi (Not In First Six Researchers), Hamid Nadri (Not In First Six Researchers), Yaghoub Sarrafi (Not In First Six Researchers), Yaghoub Pourshojaei (Fifth Researcher), Loghman Firoozpour (Fourth Researcher), Mina Saeedi (Third Researcher), Leila Khosravani (Second Researcher), Samira Rahmani-Nezhad (First Researcher)