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Title
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A Facile Regioselective Synthesis of Novel Spiroacenaphthene Pyrroloisoquinolines Through 1,3-Dipolar Cycloaddition Reactions
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Type
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JournalPaper
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Keywords
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1,3-dipolar cycloaddition; azomethine ylide; [1,5]-H shift; spiroacenaphthene pyrroloisoquinolines
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Abstract
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An efficient one-pot three-component procedure for the synthesis of novel spiroacenaphthene pyrroloisoquinolines with high regioselectivity is described. These compounds were prepared from 1,3-dipolar cycloaddition of an azomethine ylide generated from acenaphthenequinone and 1,2,3,4-tetrahydroisoquinoline via [1,5]-H shift, with chalcone and nitrostyrene derivatives as dipolarophiles. The structure and stereochemistry of the cycloadducts have been established by single crystal X-ray structure and spectroscopic techniques.
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Researchers
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Marzieh Sadatshahabi (Fifth Researcher), Kamal Alimohammadi (Fourth Researcher), Mahshid Hamzehloueian (Third Researcher), Asieh Asghari (Second Researcher), Yaghoub Sarrafi (First Researcher)
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