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Title
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Protective role of Pleurotus porrigens (Angel’s wings) against gentamicin-induced nephrotoxicty in mice
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Type
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JournalPaper
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Keywords
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Angel’s wings, Creatinine, Gentamicin, Nephropro- tective activity, Serum urea.
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Abstract
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Abstract. – Objectives: This study was conducted to quantitatively evaluate the recov- ery effects of methanolic fraction Angel’s wings on gentamicin (GM)-induced nephrotoxicity. Material and Methods: Renal injury was achieved by injecting 100 mg/kg, intraperitonealy of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 consecutive days of treatment. Results: Results show that GM-induced nephrotoxic animal model was successfully prepared. Methanolic fraction of Angel’s wings attenuated the gentamicin-induced increase in level of serum creatinine, serum urea, and blood urea nitrogen. Conclusions: The present study shows that the extract at the doses 200 and 400 mg/kg, intraperitoneally offered significant nephroprotective action that is comparable with control group.
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Researchers
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Akbar Hajizadeh Moghaddam (First Researcher), Mohammad Ali Ebrahimzadeh (Not In First Six Researchers), SEYED MOHAMMAD NABAVI (Fifth Researcher), SEYED FAZEL NABAVI (Third Researcher), Mohammad Reza Mahdavi (Fourth Researcher), Mahdieh Javaheri (Second Researcher)
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