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Title
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Cannabinoid System of the Lateral Septum in the Modulation of Anxiety-like Behaviors in Rats
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Type
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JournalPaper
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Keywords
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Anxiety, cannabinoid, lateral septum, plus-maze test, rat
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Abstract
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Backgrounds: A large body of evidence suggests that the cannabinoid CB receptor plays a key role in the regulation of emotional behaviors. The present study was designed to evaluate the effects of CB 1 1 agonist and antagonist on anxiety-like behaviors in the lateral septum (LS) region of the rat brain using elevated plus maze test. Method: Rats were anesthetized with ketamine and xylazine and special cannulas were inserted stereotaxically into the LS region. After 1 week of recovery, the effects of intra-LS administration of the CB 1 receptor antagonist, AM251, 1 Results: 55,212-2-induced anxiogenic-like effects. Conclusions: The results suggest that the cannabinoid system of the lateral septum modulates anxiety-like behavior through CB 1 receptor.
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Researchers
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Akbar Hajizadeh Moghaddam (First Researcher), ali roohbakhsh (Fourth Researcher), Seyed Reza Fatemi Tabatabaei (Third Researcher), Rata Bigdellu (Second Researcher)
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