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Title
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Guanidine hydrochloride as an organocatalyst for N-Boc protection of amino groups
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Type
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JournalPaper
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Keywords
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Protection, Organocatalysis, (Boc)2O, Amines, Amino acids
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Abstract
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A simple and efficient method for the chemoselective N-Boc protection of the amine moiety in a variety of compounds is described using di-tert-butyl dicarbonate and guanidine hydrochloride as an organocatalyst in ethanol at 35–40 C. Selective mono-N-Boc protection of diamines and chemoselective protection of hydroxylamines without formation of any side products is achieved. Amino acids and peptides are N-Boc protected efficiently in excellent yields under convenient reaction conditions.
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Researchers
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samad khaksar (Fourth Researcher), mahmood tajbakhsh (Second Researcher), Fatemeh Jahani Bahnamiri (First Researcher), Hamid Golchoubian (Third Researcher)
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