مشخصات پژوهش

عنوان	MHC Class I & II Restricted hTERT Derived Peptides in Cancer Immunotherapy
نوع پژوهش	مقاله ارائه شده
کلیدواژه‌ها	hTERT, MHC, Peptide-based vaccine, Cancer immunotherapy
چکیده	Introduction:Breast cancer has the highest incidence rate in women in the world. telomerase is the most common tumorassociated antigen (taa) and its activity increased in more than 90% of cancers, thus, its targeting can be used as a cancer control. Methods: In this study as a continuing in vitro studies, we re-analyzed htert selected peptides against mice MHC with iedband epimhc database. about 5 × 105 mouse breast cancer 4t1 cells was washed and suspended in 100 μl normalsaline and s.c injected to mammary fat pat of balb/c mice and then start to tumor measurement 2 times a week.about 100 ug klh conjugated peptides accompany incomplete freund′s adjuvant were injected s.c in days 10th and 20th after cancer cells inoculation. Results:The analysis of peptides shown they are can binding to mice mhc i and ii respectively but score of them is significantly lower than their interaction with human HLA. Conclusion:The results were shown contemporary mhc restricted peptide as a vaccine, can inhibit tumor growth and also increase overall survival of vaccinated mice compare untreated group.
پژوهشگران	غلامعلی کاردر (نفر ششم به بعد)، اباصلت حسین زاده کلاگر (نفر پنجم)، رضا فالک (نفر چهارم)، آرزو گوهری شبگاه (نفر سوم)، جمشید قلی زاده نواشنق (نفر دوم)، امیر محمدی (نفر اول)