|
چکیده
|
Background and aim: CYP1A1 is a metabolizing enzyme that is central to PAH detoxification. Key polymorphisms in this gene may contribute to the risk of ischemic stroke. This study aimed to investigate the association of rs4646903 gene polymorphism of CYP1A1 with ischemic stroke risk within the Asian population in a meta-analysis approach. Materials and methods: Relevant published papers were recognized by a literature search in the EMBASE, PubMed, Scopus, and Google Scholar databases. After the screening procedure, three eligible studies with Korean, Indian, and Chinese ethnicity were included in our meta-analysis. The association between CYP1A1 rs4646903 genetic variations and stroke risk was estimated by odds ratio (OR) with 95% confidence interval (CI) in six over-dominant, dominant, recessive, codominant homozygous, codominant heterozygous, and allelic inheritance models. Results: Our findings revealed that there was no significant association between rs4646903 gene polymorphism and ischemic stroke risk in any of the aforementioned six genetic models (P0.05). Conclusion: Based on our results, rs4646903 could not be considered as a molecular risk factor for ischemic stroke in the Asian population. However, a meta-analysis including more eligible studies is required to obtain more accurate outcomes. Method & Materials: Materials and methods: Relevant published papers were recognized by a literature search in the EMBASE, PubMed, Scopus, and Google Scholar databases. After the screening procedure, three eligible studies with Korean, Indian, and Chinese ethnicity were included in our meta-analysis. The association between CYP1A1 rs4646903 genetic variations and stroke risk was estimated by odds ratio (OR) with 95% confidence interval (CI) in six over-dominant, dominant, recessive, codominant homozygous, codominant heterozygous, and allelic inheritance models. Result & Conclusion: Results: Our findings revealed that there was no significant association between rs4646903 gene polymorphism and ischemic stroke risk in any of the aforementioned six genetic models (P0.05). Conclusion: Based on our results, rs4646903 could not be considered as a molecular risk factor for ischemic stroke in the Asian population. However, a meta-analysis including more eligible studies is required to obtain more accurate outcomes.
|