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چکیده
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Metformin modification and side effects have been a long concern for diabetics who do not need to use this drug frequently and continuously in order to be safe from its side effects over time. This study used a simple method to produce Met.@SiO2/PVA nanofibers using varying amounts of metformin (0.025, 0.05, and 0.1 g) and 7-weight percent PVA. FT-IR was used to examine the molecular interactions between the components. FE-SEM and UV spectroscopy were used to study the morphological analysis and drug release. The release of the drug was investigated in the presence of 0.005g of Met.@SiO2/PVA gels containing three different metformin concentrations (5, 7, and 9). The findings demonstrated that metformin releases less gradually at pH = 7 than it does at pH = 5 and 9. About 10% of the 0.025 g of metformin loaded on NF/Silica at pH=7 was released in the first hour, compared to nearly 12% and 40% for the corresponding 0.05 g and 0.1 g. For 250 hours, metformin was released at pH = 7 (0.025 g), reaching nearly 30% of its total concentration. At pH = 5, the release kinetics mechanism of the Met. (0.025 g) @SiO2/PVA carrier was in agreement with the Korsmeyer–Peppas model, confirming that diffusion was the primary mechanism controlling drug release. At pH = 9, however, the kinetics mechanism of the Met. (0.025 g) @SiO2/PVA carrier was in accordance with the Higuchi model. Excellent potential for treating type 2 diabetes is suggested by the process and structures generated in this study.
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