مشخصات پژوهش

صفحه نخست /Chronic exercise training ...
عنوان Chronic exercise training versus acute endurance exercise in reducing neurotoxicity in rats exposed to lead acetate
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها neural regeneration; neurorehabilitation; long-term exercise training; endurance exercise; treadmill; lead poisoning; neurotoxicity; oxidative stress; hippocampus; brain-derived neurotrophic factor; neuro regeneration
چکیده After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15–22 m/min, 25–64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived neurotrophic factor level in the hippocampus (P = 0.04) and plasma level of total antioxidant capacity of rats exposed to lead acetate (P < 0.001), and significantly decreased plasma level of malondialdehyde (P < 0.001). Acute exercise only decreased the hippocampal malondialdehyde level (P = 0.09) and increased brain-derived neurotrophic factor level in the hippocampus (P = 0.66). Acute exercise also enhanced the total antioxidant capacity in rats exposed to lead acetate, insignificantly (P = 0.99). These findings suggest that chronic treadmill exercise can significantly decrease neurotoxicity and alleviate oxidative stress in rats exposed to lead acetate. However, acute endurance exercise was not associated with these beneficial effects.
پژوهشگران وگیناک سارکیسیان (نفر پنجم)، سلیمان محجوب (نفر چهارم)، سمیه حسین زاده (نفر سوم)، ولی اله دبیدی روشن (نفر دوم)، محمد شاهنده (نفر اول)