مشخصات پژوهش

صفحه نخست /Endurance exercise training ...
عنوان Endurance exercise training and diferuloyl methane supplement: changes in neurotrophic factor and oxidative stress induced by lead in rat brain
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها lead, endurance exercise, diferuloyl methane supplement, BDNF, oxidative stress
چکیده Lead is a highly neurotoxic agent that particularly affects the developing central nervous system. In the current study we investigated the neuroprotective effects of exercise training and/or diferuloyl methane (DM) supplement, which is known as curcumin, on lead acetate-induced neurotoxicity in the rat hippocampus. Sixty rats were randomly divided into six groups: 1) lead acetate, 2) DM supplement, 3) endurance training, 4) training+ DM supplement, 5) sham and 6) base. The rats in the training groups performed treadmill running consisting of 15 to 22 m· min-1 for 25 to 64 min, 5 times a week for 8 weeks. All groups except sham received lead acetate (20 mg· kg-1), whereas the sham group received DM solvent. In addition, the DM and training+ DM groups received DM solution (30 mg· kg-1) intraperitoneally. Chronic administration of lead acetate resulted in a significant increase in the malondialdehyde (MDA) in plasma, but not in the hippocampus. In addition, it led to significantly decreased brain-derived neurotrophic factor (BDNF) in the hippocampus and total antioxidant capacity (TAC) levels, as compared to the sham group. Treadmill running, DM supplementation, or both resulted in a significant decrease in MDA levels and significantly increased BDNF and TAC levels, as compared to the lead acetate group. These results provide a rationale for an inhibitory role of DM supplement and regular exercise in the attenuation of lead-induced neurotoxicity.
پژوهشگران جاناتان میرز (نفر پنجم)، مهدی حسین زاده (نفر چهارم)، سلیمان محجوب (نفر سوم)، سمیه حسین زاده (نفر دوم)، ولی اله دبیدی روشن (نفر اول)