مشخصات پژوهش

عنوان	Ephedra intermedia Schrenk & C. A. Mey Methanol Extract: Nanoencapsulation by Mini‐Emulsion Polymerization and its Release Trend under Simulated Conditions of the Human Body
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Ephedra intermedia Schrenk & C. A. Mey, Nanoencapsulation, Mini-Emulsion Polymerization, Human Body
چکیده	In this research, the extract of Ephedra intermedia Schrenk & C.A.Mey. was encapsulated using the mini-emulsion polymerization method based on methyl methacrylate polymers with a nanometer size. The encapsulated extract was characterized using different analytical techniques. Furthermore, the loading efficiency and release of the plant extract were examined. FT-IR spectroscopy confirmed the formation of an expectational product. The TEM and SEM imaging showed a spherical morphology for the prepared encapsulated extract. The average size of poly-methyl-methacrylate nanoparticles containing Ephedra extract was found to be approximately 47 nm. The extract loading efficiency and encapsulation efficiency test demonstrated a dose-depending behavior on E. intermedia extract for both analyses, which is highly advantageous for traversing biological barriers. The release assay shows a controlled release for the extract at phosphate buffer solution (PBS). A 38 % release was calculated after 36 hours. The results obtained from the present study reveal that encapsulating the plant extract is a suitable alternative to control and increase their medicinal properties.
پژوهشگران	مجید محمدحسینی (نفر پنجم)، بهروز ملکی (نفر چهارم)، غلامعلی فرزی (نفر سوم)، ساناز ابراهیمی (نفر دوم)، بهنام مهدوی (نفر اول)