مشخصات پژوهش

عنوان	Synthesis and structure-activity relationship study of benzofuranbased chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors
نوع پژوهش	مقاله چاپ شده
کلیدواژه‌ها	Acetylcholinesterase Alzheimer's disease Benzofuran Docking study Pyridinium
چکیده	A series of benzofuran-based chalconoids 6aev were designed and synthesized as new potential AChE inhibitors. The in vitro assay of synthesized compounds 6aev showed that most compounds had significant anti-AChE activity at micromolar or sub-micromolar levels. Among the tested compounds, 3- pyridinium derivative 6m bearing N-(2-bromobenzyl) moiety and 7-methoxy substituent on the benzofuran ring exhibited superior activity. This compound with IC50 value of 0.027 mM was as potent as standard drug donepezil.
پژوهشگران	عباس شفیعی (نفر ششم به بعد)، علیرضا فرومدی (نفر ششم به بعد)، حشمت اله علی نژاد (نفر ششم به بعد)، سعید امامی (نفر ششم به بعد)، حمید نادری (نفر پنجم)، علیرضا مرادی (نفر چهارم)، محمد مهدوی (نفر سوم)، قدسی محمدی زیارانی (نفر دوم)، منیژه مستوفی (نفر اول)