Optimization of 2-propanol oxidation over CuMnmCo2mO4 nanospinels was carried out by a split design method. 15-term model was proposed to fit the experimental data. The model revealed that both whole plot and subplot variables have significant effects on conversion of 2-propanol. The model predicted the interaction of subplot and whole plot variables as well as their importance. The maximum conversion of 2-propanol was observed over CuMn2O4 (x1 = 0.33, x2 = 0, x3 = 0.67) at calcination and reaction temperatures of 800 8C (z1 = 1) and 300 8C (z2 = 1), respectively. The predicted response and the response obtained from experiment for optimum conditions were 93.36 and 96, respectively
