Some parasites can be transferred from fish to human via eating of contaminated meat and make serious problems in consumers. In the present study zoonotic parasites of abdominal cavity in pike-perch, Sander lucioperca, in south eastern part of the Caspian Sea have been surveyed. In this regard, 30 fish were caught by purse seine net and abdominal cavity, digestive tract and other organs (kidney, spleen, liver, gonads and mesentery) of specimens were fully examined for helminthic parasites. Totally two zoonotic nematodes including Anisakis simplex and Eustrongylides sp were isolated from pike-perch. According to the result, 46.67 % of specimens were infected at least with one type of mentioned parasites. In this study the prevalence of Anisakis simplex and Eustrongylides sp infections in pikeperch were recorded as 36.67 % and 23.33 %, respectively. Mean intensity of parasite infection were calculated as 12.13 ± 5.8 and 2.57 ± 1.51, respectively for Anisakis simplex and Eustrongylides sp in pike-perches. This study described that the pike-perches in south-eastern part of the Caspian Sea are infected with mentioned zoonotic parasites, so health care of consumers in this area should be considered.