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Shadmehr Mirdar Harijani

Shadmehr Mirdar Harijani

Academic rank: Professor
Education: PhD.
Faculty: Faculty of Physical Education and Sports Sciences
Address: Professor of Exercise Physiology, Dep. of Exercise physiology, Faculty of sports Sciences, University of Mazandaran P.O.Box 47415-388 Babolsar,Mazandaran Province, IRAN Tel: +98 +111+35302201 & 35302254 Fax: +98+ 111+35302201
Phone: 01135302254


Effect of a 12-week submaximal swimming training in rats exposed to tobacco- derived nitrosamine ketone
Interleukin 10, Tobacco-derived nitrosamine ketone, Submaximal aerobic activity, Inflammation.
Journal caspian journal of internal medicine
Researchers ali Barzegari ، Shadmehr Mirdar Harijani


Background: Tobacco contains carcinogens such as NNK (nicotine-derived nitrosamine ketone) that makes induction of lung cancer by changing the stimulation of IL-10 expression. The aim of this study was to investigate changes in resting levels of IL-10 in lung tissues of rats exposed to NNK after a 12-week aerobic submaximal swimming training. Methods: For this purpose, 46 Wistar rats were randomly divided into five groups consisting training, training + NNK, NNK, saline and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. The levels of IL-10 in homogenized lung tissue were measured by ELISA. Results: Findings indicated that a period of swimming training increased the IL-10 levels significantly in lung tissue of training group when compared to control (P=0.00) and NNK groups (P=0.00). Also, a significant increase of IL-10 level was observed in exercise + NNK group when compared to NNK group (p≤0/02). Furthermore, it was observed that IL-10 levels of NNK group had a significant decrease when compared to training group (P=0/00), training + NNK group (p≤0/02), but had insignificant increase when compared to saline group (p≤0/85). Conclusions: Generally, it could be confirmed that regular submaximal aerobic training plays an important role in the inhibition of the effects of lung inflammation induced by NNK via increasing IL-10 activity.