Background & Objectives: BK and JC viruses belong to the polyomavirus family.These two viruses are latently and chronically established in the body and are reactivated under factors such as pregnancy, organ transplantation, aging that weaken the immune system. Miscarriage/abortion is one of the most common complications of pregnancy and it refers to cases that terminate pregnancy before the 20th week of pregnancy for various reasons such as fetal and maternal reasons. Due to the high prevalence of miscarriage/abortion in pregnant women and considering the importance of this issue, the molecular relationship of BK and JC viruses with abortion was investigated. Materials and Methods: This study was conducted on 100 people with an age range of 18-42 years, including 50 pregnant women with a history of miscarriage/abortion and 50 pregnant women without a history of miscarriage/abortion as a control group. After extracting the genome from urine, the presence of BK and JC viruses was investigated using specific primers and the polymerase chain reaction molecular method. Results: According to this study, in the urine of 2 people (4%) from the control group and 4 people (8%) from the samples with a history of miscarriage/abortion, BK virus, as well as 7 people (14%) from the control group and 14 people (28%) from Samples with a history of miscarriage/abortion were diagnosed with JC virus. Conclusion: Statistical analysis did not show a significant relationship between the presence of the virus and miscarriage/abortion, but a significant relationship was found between the presence of these viruses and age over 30 years. Considering the importance of the topic and the high number of JC virus positive cases in women with a history of miscarriage/abortion compared to the control group, it is possible that this research will show different results by increasing the number of examined samples, so further investigations are suggested.
