In this study, adsorption kinetic of cesium, strontium and rubidium radionuclides was investigated using ferritin magnetic molecules. Kinetic investigation of synthetic and natural wastes was carried out and the results were compared. Pseudo first-order, pseudo second-order, Elovich, double-exponential, and intraparticle diffusion models were the kinetic models used in the fitting of experimental data. The kinetic study of synthetic waste revealed that the double-exponential model demonstrated excellent fitting. Coefficient of determination resulting from fitting of cesium, strontium, and rubidium radionuclide’s adsorption results via the double-exponential model are 0.9938, 0.9905, and 0.9863 respectively. In the experiments conducted on natural wastes, too, all of the five kinetic models were investigated. Results indicated that the double-exponential model matched greatly with the experimental data, and cesium, strontium, and rubidium radionuclide’s coefficients of determination were 0.9742, 0.9613, and 0.9442 respectively. Comparison of the results of natural and synthetic wastes showed that matching with the model and recovery of target elements were more prominent in experiments with synthetic waste (unicomponent) rather than natural waste (multicomponent).