Because of the intricate nature of real-world scenarios, experts could encounter many ambiguities throughout the decision-making (DM) process. Adopting a DM strategy in conditions of indeterminacy so that the decision makers are limited to a small number of experts is always helpful in real life. Neutrosophic conception is a convenient technique for handling inconsistent, ambiguous, and uncertain values. This research presents an autocratic DM strategy based on Neutrosophic Sets (NSs) to address these ambiguities. The essential component of the suggested technique is the conversion of diverse management decision and weight matrices into a unified evaluation matrix. Supplier Selection (SS) is a multi-criteria decision-making problem where a limited number of alternative suppliers are evaluated using a limited set of criteria. The suggested methodology based on different score functions is applied to SS issues involving construction materials. The numerical illustrations indicate the success of the introduced method in selecting the best supplier with the least computational complexity. The important point obtained in this research is that adopting a suitable score function appropriate to the characteristics of the data plays an important role in the decision-making process.