The potential of light nuclei, such as deuteron, tritium, and helium isotopes, are studied using a noncritical holographic QCD model constructed in the six-dimensional anti–de Sitter (AdS6) supergravity background. The nucleus potentials are considered as a sum of the nucleon-nucleon potentials. The nucleon-meson coupling constants evaluated from the noncritical holography QCD model are used to obtain these potentials. The potential of both ground state and available excited states of these nuclei are well studied using this model. The binding energy of nuclei has been estimated. Also, the excited energy for the nuclei are roughly calculated. There is good agreement between the noncritical holography model results and the experimental data.