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Maryam Mohadjerani

Maryam Mohadjerani

Academic rank: Associate Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Science
Address: Department of Molecular and Cell Biology, Faculty of basic sciences . .University of Mazandaran, Babolsar, Mazandaran, Iran
Phone: 01135302455

Research

Title
T4216C mutation in NADH dehydrogenase I gene is associated with recurrent pregnancy loss
Type
JournalPaper
Keywords
Recurrent pregnancy loss (RPL), mitochondrial NADH dehydrogenase I (ND1), T4216C mutation
Year
2013
Journal Mitochondrial DNA
DOI
Researchers Abasalt Hosseinzadeh Colagar ، Elahe Mosaieby ، SEYED MOHAMMAD SEYEDHASSANI ، Maryam Mohadjerani ، AHOORA ARASTEH ، BEHNAM KAMALIDEHGHAN ، MASSOUD HOUSHMAND

Abstract

Several genetic factors are involved with recurrent pregnancy loss (RPL). However, few attempts have been made to associate mitochondrial DNA (mtDNA) variations with RPL. Therefore, we investigated the possible effect of the T4216C mutation in the mitochondrial NADH dehydrogenase I (ND1) gene of 33 women with RPL and 100 controls, using polymerase chain reaction amplification and DNA sequence analysis. Our results showed a statistically significant association of the T4216C mutation (p < 0.05) between patients and controls, which are 30% and 11%, respectively. In conclusion, more research is essentially needed to understand the effect and role of the T4216C mutation in the progress of RPL, which may vary among individuals and different ethnic groups.