Background and Objectives: The association of Q7R polymorphism with Alzheimer disease has been investigated in several studies of different populations and conflicting results were found among them. For this reason, this meta-analysis performed to determine whether Q7R saitohin polymorphism is associated with susceptibility to Alzheimer disease in Caucasian population. Methods: A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies in Caucasian population. The pooled odds ratios (ORs) with 95% confidence intervals were calculated to evaluate the association of Q7R polymorphism with Alzheimer disease. Association of Q7R saitohin polymorphism evaluated under dominant, recessive, co-dominant, and allelic models. Results: The ORs for the Q7R saitohin polymorphism and Alzheimer disease were indicative of positive association under recessive genetic models. The results indicated that Q7R saitohin polymorphism was significantly associated with the increased risk of Alzheimer disease in recessive model (RR vs. QR+QQ: OR =1.555 [95%CI: 0.985-2.454]; p= 0.05). Conclusions: In summary, Q7R saitohin polymorphism is positively associated with the increased risk of Alzheimer disease in Caucasian population, especially the homozygous carriers. It could be of value to investigate its association with Alzheimer disease in combination with additional risk factors. However, very large studies with different ethnic population are required to accurately demonstrate the role of this candidate gene in development of Alzheimer disease.
