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Ali Akbar Ashkarran

Ali Akbar Ashkarran

Academic rank: Assistant Professor
ORCID:
Education: PhD.
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Phone: 01135302485

Research

Title
Gold nanocages decorated biocompatible amine functionalized graphene as an efficient dopamine sensor platform
Type
JournalPaper
Keywords
Gold nanocages Graphene Nanocomposite Thermal treatment Dopamine Amperometric detection
Year
2017
Journal JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI
Researchers Sahar Daemi ، Ali Akbar Ashkarran ، Ali Bahari ، Shahram Ghasemi

Abstract

Nanocomposite of gold nanocages and chemically modified graphene oxide (GNCs/CMG) was synthesized in N,N-dimethylformamide (DMF) for sensitive detection of dopamine (DA). DA is widely spread in central nervous system which can regulates essential body functions like movement and emotional behaviour. In this regard sensitive and fast detection of DA level in human body is still challenging considering its interference with other biomolecules in biological samples. CMG was synthesized through amine modification of graphene oxide (GO) with DMF at relatively high temperature followed by attachment of GNCs, fabricated using a galvanic replacement between silver nanocubes and HAuCl4 solution in the DMF. X-ray diffraction (XRD) pattern of GNCs/CMG nanocomposite revealed high crystallization of GNCs attached to the graphene nanosheets and microscopic images revealed relatively uniform decoration of GNCs on the surface of CMG. Nanocomposite modified glassy carbon electrode (GNCs/CMG/GCE) was used to investigate the electrochemical behaviour of DA with cyclic voltammetry and amperometry techniques. The linear range for dopamine was between 0.1 and 80 lM with a low detection limit of 0.02 lM. Furthermore, GNCs/CMG/GCE exhibited satisfying reproducibility, long-term stability and high selectivity for DA detection in large amount of ascorbic acid with good results for determination in human serum samples.