In research or experimental works related to blast loads, the amount of explosion material and distance of explosion point are very important. So, in this paper has been attempted to present a parametric study of the reactive powder concrete subjected to blast load. The effect of the different amount of TNT adopted the literature, distance of explosion point from RPC slab and also the location of explosion charge (horizontal and vertical coordinates form the center of specimens) has been investigated. In order to the analytical simulation of RPC behavior against blast and also the accuracy of acquired results, at first using ABAQUS software, a RPC slab studied in the literature has been verified. The obtained results are showed that the simulated model of RPC is match with literature one. In the next stage, a case study of the effect of explosion charge and also the distance of explosion point from RPC and NSC (normal strength concrete) slabs have been examined, and the results have been compared. It’s noted that the NSC slab is supposed to be a reinforced concrete, whereas 2% volume of special short steel fibers were used in the RPC specimen. The acquired results have been showed that the RPC have better blast explosion resistance than reinforced normal strength concrete.