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Title
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Nano silica‑bonded aminoethylpiperazine: a highly efficient and reusable heterogeneous catalyst for the synthesis of 4H‑chromene and 12H‑chromeno[2,3‑d]pyrimidine derivatives
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Type
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JournalPaper
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Keywords
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Nano silica, Aminoethylpiperazine, Basic catalyst, Chromene
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Abstract
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The reaction of nano silica with 3-chloro-propyltrimethoxysilane followed by treatment with ami-noethylpiperazine afforded nano silica-bonded aminoeth-ylpiperazine (SB-APP). The structure of the synthesized SB-APP was characterized by FT-IR, TGA, BET, SEM and elemental analysis and identified as an efficient basic catalyst for the preparation of 2-amino-4H-chromenes and 12H-chromeno[2,3-d]pyrimidine derivatives. One-pot three-component reaction of phenols, aromatic alde-hydes and malononitrile in the presence of the catalytic amounts of SB-APP afforded high yield of the correspond-ing 2-amino-4H-chromenes under mild reaction condi-tions. 12H-Chromeno[2,3-d]pyrimidines were successfully synthesized with reasonable yield by reacting the 2-amino-4H-chromenes with acetic anhydride in the same pot with-out purification of the corresponding chromene intermedi-ates. All products were characterized by FT-IR, 1H NMR, 13C NMR and MS data. The catalyst was simply recovered from the reaction mixture and reused several times without significant loss of catalytic activity.
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Researchers
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mahmood tajbakhsh (First Researcher), Mohammadreza Azizi Amiri (Not In First Six Researchers), Helia Janatian Gazvini (Not In First Six Researchers), Mahgol Tajbakhsh (Not In First Six Researchers), Parizad Rezaei (Fifth Researcher), Rahman Hosseinzadeh (Fourth Researcher), Heshmatollah Alinezhad (Third Researcher), Mohadeseh Kariminasab (Second Researcher)
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