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Title
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Synergic Effect of Cu/TiO2 Nanocomposite, 2-(ferrocenylethynyl)fluoren-9-one and Room Temperature Ionic Liquid for the Fabrication of Highly Sensitive Voltammetric Sensor for Levodopa Determination in the Presence of Tyrosine
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Type
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JournalPaper
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Keywords
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Levodopa, Tyrosine, Cu/TiO2 nanocomposite, Room temperature ionic liquid, 2-(ferrocenylethynyl)fluoren-9-one, Carbon paste electrode, Voltammetry
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Abstract
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Levodopa, one of the prescribed medications in Parkinson disease, is electrochemically determined here. A Cu/TiO2 nanocomposite/room temperature ionic liquid/2-(ferrocenylethynyl)fluoren-9-one modified carbon paste electrode (Cu/TiO2-IL- 2FF/CPE) was used for the electrochemical determination of levodopa. The electro-oxidation mechanism of levodopa at Cu/TiO2-IL-2FF/CPE was also studied. The obtained data showed that the electro-oxidation of levodopa at the Cu/TiO2-IL-2FF/CPE is greatly facilitated, which is attributed to high electrical conductivity of Cu/TiO2 nanocomposite, room temperature ionic liquid and 2-(ferrocenylethynyl)fluoren-9-one. The Cu/TiO2-IL-2FF/CPE showed a good electron mediating behavior followed by well separated oxidation signals of levodopa and tyrosine. Differential pulse voltammetric peak current showed a linear relationship corresponds to the concentrations of levodopa in a linear range of 0.03 to 700.0 μM with detection limit of 12.0 nM. The Cu/TiO2-IL-2FF/CPE shows excellent ability to determination of levodopa and tyrosine in real samples.
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Researchers
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Rahman Hosseinzadeh (Not In First Six Researchers), Pourya Biparva (Not In First Six Researchers), Hadi Hassani (Fifth Researcher), Shohreh Jahani (Fourth Researcher), Hadi Beitollahi (Third Researcher), Somayeh Tajik (Second Researcher), Sedighe Akbari (First Researcher)
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