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Title
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Voltammetric determination of D-penicillamine based on its homogeneous electrocatalytic oxidation with potassium iodide at the surface of glassy carbon electrode
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Type
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JournalPaper
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Keywords
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potassium iodide, penicillamine, voltammetric determination, homogeneous electrocatalysis
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Abstract
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The electrooxidation of D penicillamine (D PA) has been studied in the presence of potassium iodide in various buffered aqueous solutions (4.00 ≤pH ≤9.00) at the surface of glassy carbon electrode using cyclic voltammetry, differential pulse voltammetry and chronoamperometry. It has been found that under optimum pH (pH 5.00) in cyclic voltammetry, the electrooxidation of D PA in the presence of potassium iodide as a homogeneous mediator occurred at a potential about 220 mV less positive than that in absence of potassium iodide at the surface of glassy carbon electrode. The homogeneous electrocatalytic oxidation current wave of D penicillamine was linearly dependent on the D-PA concentration and a linear calibration curve was obtained in the ranges 3.0 ×10–5 –1.5 ×10–3 M and 9.0 ×10–6 –1.2 ×10–4 M of D-PA with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods, respectively. The detection limits (2σ) were determined as 3.0 ×10–5 and 3.5 ×10–6 M with CV and DPV, respectively. This method was also used for voltammetric determination of D PA in pharmaceutical preparation by standard addition method.
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Researchers
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Fereshteh Chekin (Fourth Researcher), Mahsa Majidian (Third Researcher), Reza Ojani (Second Researcher), Jahan Bakhsh Raoof (First Researcher)
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