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Title Catalyst-free one-pot synthesis of 1,4,5-trisubstituted pyrazoles in 2,2,2-trifluoroethanol
Type JournalPaper
Keywords 2,2,2-Trifluoroethanol Pyrazole Cyclization Enaminone
Abstract A simple, efficient and three component one-pot synthesis of 1,4,5-trisubstituted pyrazoles by condensation of β-dicarbonyls, N,N-dimethylformamide dimethyl acetal (DMFDMA) and hydrazine derivatives in 2,2,2-trifluoroethanol without using any catalyst and activation, is described.
Researchers Mahboobeh Zare (Third Researcher), mahmood tajbakhsh (Second Researcher), Heshmatollah Alinezhad (First Researcher)