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Title
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Catalyst-Free One-Pot Reductive Alkylation of Primary and Secondary Amines and N,N-Dimethylation of Amino Acids Using Sodium Borohydride in 2,2,2-Trifluoroethano
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Type
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JournalPaper
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Keywords
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reductive amination - 2,2,2-trifluoroethanol - sodium borohydride - reductive methylation
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Abstract
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A simple and convenient procedure for the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids is described using sodium borohydride as a reducing agent in 2,2,2- trifluoroethanol without use of a catalyst or any other additive. The solvent can be readily recovered from reaction products in excellent purity for direct reuse.
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Researchers
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samad khaksar (Not In First Six Researchers), akbar heydari (Fifth Researcher), Somayeh Ghahari (Fourth Researcher), Heshmatollah Alinezhad (Third Researcher), Rahman Hosseinzadeh (Second Researcher), mahmood tajbakhsh (First Researcher)
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